Cancer molecular diagnostics

Precision oncology,
made smart.

Most patients with advanced cancer never get the genomic test that would tell their oncologist which therapy to start. OncoX builds diagnostics that change that — fast, ultra-sensitive, and designed to run in the labs that already serve them.

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The gap in precision oncology

Half of advanced-cancer patients are denied the genomic testing that could guide their treatment.

Tissue is often insufficient, turnaround is too slow, and the equipment cost shuts most labs out. The result: patients start chemotherapy when they could have started a targeted therapy.

Source: DaCosta et al. JAMA Network Open 2025;8(7):e2519963.

>50% of advanced-cancer patients are denied access to precision oncology by a lack of genomic testing
25% of lung cancer samples fail current biomarker testing
3+ wks typical turnaround from biopsy to genomic results
$2–5M cost to stand up clinical genomic sequencing in a single lab
LiquiSmart Lung · Comprehensive coverage

All 11 recommended genes — in 1 test.

The 11 genes and 114 variants that determine which therapy a lung-cancer patient should start — covered in a single assay. LiquiSmart Lung detects 99% of the DNA mutations and >97% of the gene fusions known to drive non-small cell lung cancer (Cosmic v100), from a single FFPE block or a tube of blood.

11therapy-defining genes
114variants covered
77DNA variants
37RNA fusions
100%specificity
EGFRDNAExon 18/19/20/21 — incl. T790M, C797S, L858R
KRASDNAG12/G13/Q61 hotspots — incl. G12C
BRAFDNAV600E exon 15
ERBB2DNAExon 17 V659E · Exon 20 insertions
ALKRNA fusionEML4-ALK and partner variants
ROS1RNA fusionAll clinically relevant fusion partners
RETRNA fusionKIF5B-RET and CCDC6-RET variants
METRNAExon 14 skipping
NTRK1RNA fusionAll NTRK1 fusion partners
NTRK2RNA fusionAll NTRK2 fusion partners
NTRK3RNA fusionAll NTRK3 fusion partners
PD-L1proteinCompanion testing recommended
Analytical performance

The new benchmark in lung-cancer genomic testing — industry-leading sensitivity, 100% specificity.

Median panel-wide LoD95 on the standard input workflow. Performance holds at low input, where most NGS workflows fail.

Tissue (FFPE) ≥10% tumor · 5 ng DNA / 1.5 ng RNA
AssayDNA SNV/indelRNA fusionsMET ex14
LoD₉₅<3% VAF<100 copies<200 copies
Specificity100%100%100%
Blood (plasma) 10 mL PAXgene® · 20 ng DNA / 42 ng RNA
AssayDNA SNV/indelRNA fusionsMET ex14
LoD₉₅0.3% VAF<6 copies<100 copies
Specificity100%100%100%
For reference, gold-standard NGS: tissue 2–5% VAF · blood (high input) 0.3–0.8% VAF · blood (low input) 1.5–2.5% VAF. LiquiSmart matches or beats NGS sensitivity at a fraction of the input — and runs on a thermal cycler your lab already owns.
Launched · CDSCO IVD clinical study underway

LiquiSmart Lung

A fast, ultra-sensitive biomarker test for non-small cell lung cancer. Detects 99% of guideline-recommended DNA mutations and >97% of gene fusions — from a single FFPE block or a tube of blood, on standard real-time PCR hardware.

Platform
qPCR-based assay
Indication
Stage IB–IV NSCLC
Sample
FFPE tissue or 10 mL blood (PAXgene®)
Turnaround
Next-day results
Coverage
11 genes · 114 variants · DNA + RNA
Status
CLIA / CAP validated · ISO 13485
Sample to insight

A workflow your lab can adopt next week.

  1. 01

    Target amplification

    Selective enrichment of all guideline regions from DNA and RNA in parallel.

    30 min hands-on · 1 h 25 m incubation
  2. 02

    Enzymatic cleanup

    Removes off-target product so signal-to-noise stays clinical-grade.

    10 min hands-on · 15 min incubation
  3. 03

    LiquiSmart reaction

    Variant-discriminating chemistry that lights up only the alleles you're looking for.

    35 min hands-on · 35 min incubation
  4. 04

    Detection

    Real-time PCR readout on standard QuantStudio™ hardware your lab already runs.

    15 min hands-on · 3 h 30 m run
  5. 05

    Report

    Desktop analysis returns a clinician-ready report — actionable variants and confidence calls.

    5 min hands-on · next-day result
Independently validated

Tested in the labs that set the standard.

  • ISO 13485 manufacturing for reagents.
  • CLIA-certified, CAP-accredited US laboratory clinical validation.
  • CellCarta CRO independent validation for clinical-trial use in the US, EU and China.
  • Consistent performance across multiple independent academic sites.
  • Peer-reviewed publications in Frontiers in Oncology, Journal of Liquid Biopsy, and Translational Lung Cancer Research.
MD Anderson Cancer Center Independent clinical testing
University of Pennsylvania Perelman School of Medicine
Medical College of Wisconsin Molecular pathology validation
Fred Hutch Cancer Center Reproducibility study
CellCarta CRO clinical-trial validation
CLIA / CAP US lab Clinical diagnostic validation
Patient
L.G.* · 71 years
Diagnosis
Stage IV NSCLC
Sample
Pleural biopsy — 10–15% tumor content
Prior testing
NGS & sequential PCR returned QNS

*Anonymized clinical case study, identifying details altered.

Report in 34 hours.

LiquiSmart Lung returned an actionable EGFR L858R mutation from the same low-content sample — enabling targeted therapy to begin immediately.

Patient case

When the sample is small, the result still has to count.

L.G. presented with a large pleural effusion and pleural nodularity. Pleural fluid was aspirated, but the cell block had insufficient cellularity for molecular studies. A pleural biopsy confirmed NSCLC — but at 10–15% tumor content it was deemed quantity not sufficient for NGS or sequential PCR testing.

With no molecular result, L.G. was started on chemotherapy empirically. He did not tolerate it well.

Roadmap

One company. Every cancer that deserves better diagnostics.

LiquiSmart Lung is launched. Bladder, Prostate, Breast and Head & Neck are next — built on targeted NGS where deep multi-gene profiling matters most.

ProgramIndicationPlatform DiscoveryAnalyticalClinicalLaunch
LiquiSmart LungNSCLC, Stage IB–IVqPCR (DNA + RNA)
LiquiSmart BladderUrothelial carcinomaTargeted NGS
LiquiSmart ProstatemCRPCAR-aware NGS
LiquiSmart BreastHR+/HER2− mBCHotspot NGS + dPCR
LiquiSmart H&NHPV+/− HNSCCDual-track NGS

Available in

India

Through CDSCO IVD licensing — clinical performance study underway. Discussions ongoing for additional emerging markets.

Bringing precision oncology to where it's needed most.

  • Ultra-sensitive biomarker testing in NSCLC
  • Rapid results from FFPE tissue or blood
  • Simultaneous DNA & RNA analysis
  • Industry-leading sensitivity, 100% specificity
  • Very low test failure rate
  • No new instrument capex for the lab
ONCO X

The power
of smart.

Precision oncology should not be a privilege of geography. OncoX builds the diagnostics that make sure it isn't.

Talk to us
Get in touch

Bring molecular precision to your patients.

Request kits, access clinical data, or partner with us on a new indication. We respond within one business day.

Or write to us directly at aditi.datta@biositeindia.com

LiquiSmart Lung is for in vitro diagnostic use in jurisdictions where licensed; clinical performance study underway for CDSCO IVD approval in India. Other indications in development and not yet available for clinical use.